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Researcher Information

Aaron P. Rapoport, M.D.
Gary Jobson Professor in Medical Oncology; Director, Gene Medicine/Lymphoma; Associate Director, Bone Marrow/Stem Cell Transplant Program

Department:
University of Maryland Greenebaum Cancer Center/Bone Marrow Transplant Program

UMGCC Research Program:
Experimental Therapeutics Program
Tumor Immunology and Immunotherapy

Education/Training:
College Degree: S.B., Massachusetts Institute of Technology,
Cambridge, MA
Medical Degree: M.D., Harvard Medical School, Boston, MA
Post Doctoral Degree: Intern in Medicine
Strong Memorial Hospital
University of Rochester School of Medicine
Rochester, NY
Residency: Resident in Medicine
Strong Memorial Hospital
University of Rochester School of Medicine
Rochester, NY
Fellowship: Hematology/Bone Marrow Transplantation Fellowship
Clincial Fellow in Hematology and Instructor in Medicine, Strong Memorial Hospital, University of Rochester, Rochecster, NY

Clinical Fellow in Bone Marrow Transplantion
Strong Memorial Hospital
University of Rochester School of Medicine
Rochester, NY

Research Fellow in Hematology/Marrow Transplant
Strong Memorial Hospital
University of Rochester School of Medicine
Rochester, NY
Certification: Diplomate, Internal Medicine
Diplomate, Hematology
ACLS (Advanced Cardiac Life Support) Provider

Contact Information:

Mailing Address: University of Maryland School of Medicine
22 S. Greene Street, Room N9E12
Baltimore, Maryland 21201
Email: arapoport@umm.edu
Phone: 410-328-1230
Fax: 410-328-1975

Research Interests:
1. Use of co-stimulated autologous T-cells and vaccines to enhance immune recovery after autologous stem cell transplants for hematologic malignacies.

2. Use of post-transplant immunotherapy or chemotherapy to improve upon outcomes for auto transplantation of hematologic malignancies.

3. Studies on the role of PDZ - binding kinase (PBK), a novel serine-threonine kinase, in leukemic cell growth.

Publications:
Rapoport AP, Badros A, Kiggundu E, Akpek G, Meisenberg B, Hakimian R, Mannuel H, Takebe N, Fenton R, Bolanos-Meade J, Heyman M, Gojo I, Ruehle K, Natt S, Ratterree B, Withers T, Sarkodee-Adoo C, Phillips GL, Guo C, Tricot G. Autologous stem cell stransplantation followed by consolidation chemotherapy for relapsed or refractory Hodgkin Lymphoma. Bone Marrow Transplantation, 34(10):883-890. 2004.

Takebe N, Cheng X, Wu S, Bauer K, Goloubeva OG, Fenton RG, Heyman M, Rapoport AP, Badros A, Shaughnessy J, Ross D, Meisenberg B, Tricot G. Phase I clinical trial of the inosine monophosphate dehydrogena inhibitor mycophenolate mofetil (cellcept) in advanced multiple myeloma patients. Clinical Cancer Res. 10(24): 8301-8. 2004.

Kasamon K, Drachenberg CI, Rapoport AP, Badros AZ. Catastrophic antiphospholipid syndrome: atypical presentation in the setting chronic graft versus host disease: case report and review of the literature. Haematologica/The Hematology Journal. e-cases, February/March 2005.

Badros AZ, Goloubeva O, Rapoport AP, Ratterree B, Gahres N, Meisenberg B, Takebe Naoko, Heyman M, Zwiebel J, Streicher H, Gocke CD, Tomic D, Flaws JA, Zhang B, Fenton R. Phase II sytudy of G3139, Bcl-2 Antisense, in combination with dexamethasone and Thalidomide in relapsed multiple myeloma patients. Journal of Clinical Oncology. 10.1200, 14.381. 2005.

Akpek G, Jain M, Titanji R, Rapoport, AP, Wang W, Gocke C, Cross A, Akpek G. A fatal clostridium infection in an allogeneic stem cell transplantation recipient. Bone Marrow Transplantation, 36(5): 455-457. 2005.

Nandi A, Rapoport AP. Expression of PDZ-binding kinase (PBK) is regulated by cell cycle-specific transcription factors E2F and CREB/ATF. Leukemia Research. Online publication date: 16 September 2005 doi: 10.1016/j.leukres.2005.08.011.

Crowley JA, Wang T, Rapoport AP, Ning Y. Detection of MOZ-CZB fusion in acute myeloid leukemia with 8; 16 translocation. Leukemia, 19(12): 2344-2345. 2005; Online publication date: September 29, 2005;doi: 10.1038/sj.leu.2403971.

Rapoport AP, Stadtmauer EA, Aqui N, Badros AZ, Cotte J, Chrisley L, Veloso E, Zheng Z, Westphal S, Mair R, Chi Nina, Ratterree B, Pochron MF, Natt S, Hinkle J, Sickles C, Sohal A, Ruehle K, Lynch C, Zhang L, Porter D, Luger S, Guo C, Fang H, Blackwelder W, Hankey K, Mann D, Edelman R, Frasch C, Levine BL, Cross A, June H. Restoration of immunity in lymphopenic cancer patients by vaccination and adoptive T cell transfer. Nature Medicine, 11(11): 1230-1237, 2005; Online publication date October 16, 2005; doi: 10.1038/nm1310.

Gojo I, Meisenberg B, Guo C, Badros AZ, Fassas A, Murthy A, Fenton R, Takebe N, Heyman M, Philips GL, Cottler-Fox M, Sarkodee-Adoo C, Ruehle K, French T, Tricot G, Rapoport AP. Autologous stem cell transplantation followed by consolidation chemotherapy for patients with multiple myeloma. Bone Marrow Transplantation. 37(1):65-72. 2006. Online publication date October 24, 2005; doi: 10.1038/sj.bmt.1705192.

Badros A, Weikel D, Salama A, Goloubeva O, Schneider A, Rapoport AP, Fenton R, Hahres N, Sausville E, Ord R, Meiller T. Osteonecrosis of the jaw in multiple myeloma patients: clinical features and risk factors. Journal of Clinical Oncology. 24:945-952. 2006.

Reader JC, Zhao XF, Butler MS, Rapoport AP, Ning Y. REL-positive Double Minute Chromosomes in Follicular Lymphoma. Leukemia. In press.

Dunnigan M, Yfantis H, Rapoport AP, Hosseinzadeh K, Gocke CD, Cross RK. Large cell Lymphoma presenting as a flare of colitis in a patient with common variable immune deficiency. Digestive Diseases Sciences. In press.