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Researcher Information

Hongbin Fang, Ph.D.
Assistant Professor

Department:
Epidemiology and Preventive Medicine

UMGCC Research Program:
Experimental Therapeutics Program

Education/Training:
College Degree: Ph.D., Hong Kong Baptist University
Post Doctoral Degree: 1999-2000, University of Missouri-Columbia
2001-2002, St. Jude Children's Research Hospital

Contact Information:

Mailing Address: Division of Biostatistics
Greenebaum Cancer Center
University of Maryland
22 S. Greene St.
Baltimore, MD 21201 USA
Email: hfang@umm.edu
Phone: 410-328-7828

Research Interests:
Dr. Fang's research interests include experimental design and statistical analysis for drug development, statistical methods for radiation oncology, interval censored survival and multivariate survival analysis.

Publications:
Fang, H.B., Ross, D.D., Sausville, E. and Tan, M. (2008), Experimental design and interaction analysis of combination studies of drugs with log-linear dose responses. Statistics in Medicine, in press.

Tan, M., Tian, G.L., Fang, H.B. and Ng, K.W. (2007), A fast EM algorithm for quadratic optimization subject to convex constraints. Statistica Sinica, 17(3), 945-964.

Fan T, Li R, Todd NW, Qiu Q, Fang HB, Wang H, Shen J, Zhao RY, Caraway NP, Katz RL, Stass SA and Jiang F. (2007). Up-regulation of 14-3-3(zeta) in lung cancer and its implication as prognostic and therapeutic target, Cancer Research, 67(16), 7901-7906.

Fang, H.B., Tian, G.L., Xiong, X. and Tan, M. (2006), A Restricted Multivariate Random-Effects Model with Applications to Assessing Radiation Therapy for Brain Tumors. Statistics in Medicine 25, 1948-1959.

Rapoport AP, Stadtamauer EA, Aqui N, Badros A, Cotte J, Chrisley L, Veloso E, Zheng Z, Westphal S, Mair R, Chi N, Ratterree B, Pochran MF, Natt S, Hinkle J, Sickles C, Sohal A, Ruehle K, Lynch C, Zhang L, Porter DL, Luger S, Guo C, Fang HB, Blackwelder W, Hankey K, Mann D, Edelman R, Frasch C, Levine B, Cross A, and June CH. (2005). Restoration of immunity in lymphopenic individuals with cancer by vaccination and adoptive T-cell transfer, Nature Medicine, 11(11), 1230-1237.

Fang, H.B., Tian, G.L., Xiong, X. and Tan, M. (2006), A Restricted Multivariate Random-Effects Model with Applications to Assessing Radiation Therapy for Brain Tumors. Statistics in Medicine 25, 1948-1959.

Fang, H.B, Li, G. and Sun, J. (2005), Maximum likelihood estimation in a semiparametric logistic/proportional-hazards mixture model. Scandinavian Journal of Statistics, 32, 59-75.

Tan, M., Fang, H.B., Tian, G.L. and Houghton, P.J. (2005), Repeated-measures models with constrained parameters for incomplete data in tumor xenograft experiments. Statistics in Medicine 24, 109-119.

Fang, H.B., Tian, G.L. and Tan, M. (2004). Hierarchical models for tumor xenograft experiments in drug development. Journal of Biopharmaceutical Statistics 14, 931-945.

Tan, M., Fang, H.B., Tian, G.L. and Houghton, P.J. (2003), Experimental design and sample size determination for drug combination studies based on uniform measures. Statistics in Medicine 22, 2091-2100.

Sun, J. and Fang, H.B. (2003), A nonparametric test for panel count data, Biometrika 90, 199-208.

Fang, H.B., Sun, J. and Lee, M.L.T. (2002), Nonparametric survival comparisons for interval-censored continuous data, Statistica Sinica 12, 1073-1083.

Tan, M., Fang, H.B., Tian, G.L. and Houghton, P.J. (2002), Small-sample inference for incomplete longitudinal data with truncation and censoring in tumor xenograft models, Biometrics 58, 612-620.

Fang, H.B., Fang, K.T., and Kotz, S. (2002), The meta-elliptical distributions with given marginals, Journal of Multivariate Analysis 82, 1-16.