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Researcher Information

Ming Tan, Ph.D.
Professor of Epidemiology and Preventive Medicine
Director, Biostatistics Shared Service

Department:
Epidemiology and Preventive Medicine

UMGCC Research Program:
Experimental Therapeutics Program
Tumor Immunology and Immunotherapy

Education/Training:
College Degree: B.Sc., Computational Mathematics, Wuhan University, China
Post Doctoral Degree: Ph.D., Statistics, Purdue University, West Lafayette, IN
Fellowship: Department of Biostatistics and Epidemiology, The Cleveland Clinic Foundation, Cleveland, OH

Contact Information:

Mailing Address: Biostatistics Shared Service
University of Maryland Greenebaum Cancer Center
MSTF, 261
10 S. Pine Street
Baltimore, MD 21201
Email: mttan@som.umaryland.edu
Phone: 410-706-8548
Fax: 410-706-8548

Research Interests:
Dr. Tan's independent research focuses on biostatistical methodology for the design and analysis of combination studies (testing, analyzing synergism); clinical trial designs using preclinical (xenograft) models linked with predictive clinical outcomes, group sequential methods and Bayesian methods; statistical methods for the evaluation of accuracy of diagnostic tests and cancer biomarkers and epidemiology including hierarchical modeling for longitudinal data and cancer control studies.

Publications:
Qu Y, Tan M and Kutner MH. Random-effects models in latent class analysis for evaluating accuracy of diagnostic tests. Biometrics, 52:797-810, 1996.

Tan M and Xiong X. Continuous and group sequential conditional probability ratio tests for Phase II clinical trials. Statistics in Medicine, 15:2037-2051, 1996.

Tan M, Xiong X and Kutner MH. Clinical trial designs based on sequential conditional probability ratio tests and reverse stochastic curtailing. Biometrics, 54:682-695, 1998.

Song P and Tan M. Marginal models for longitudinal proportional data. Biometrics, 56:496-502, 2000.

Tan M, Fang HB, Tian G and Houghton PJ. Small Sample Inference for incomplete longitudinal data with truncation and censoring in tumor xenograft models. Biometrics, 58:612-620. 2002.

Schwartzberg L, Petak I, Stewart C, Turner PK, Ashley J, Tillman DM, Douglas L, Tan M, Billups C, Mihalik R, Weir A, Tauer K, Shope S, and Houghton JA. Modulation of the Fas Signaling Pathway by Interferon-ƒ× in Therapy of Colon Cancer: Phase I Trial and Correlative Studies of Interferon-ƒ×, 5-Fluorouracil and Leucovorin. Clinical Cancer Research. 8:2488-2498. 2002.

Nakanishi T, Karp JE, Tan M, Doyle LA, Peters T, Yang W, Wei D, Ross DD. Quantitative analysis of breast cancer resistance protein (BCRP) and cellular resistance to flavopiridol in acute leukemia patients. Clinical Cancer Research, 9:3320-8, 2003.

Tan M, Fang HB, Tian G and Houghton PJ. Experimental design and sample size determination for testing synergy in drug combination studies based on uniform measures. Statistics in Medicine, 22: 2091-2100,2003.

Xiong X, Tan M and Boyett J. Sequential conditional probability ratio tests for normalized test statistics on information time. Biometrics, 59:624-631, 2003.

Tan M, Tian G and Ng KW. A non-iterative sampling method for computing posteriors in the structure of EM-type algorithms. Statistica Sinica. 13(3): 625-639, 2003.