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Researcher Information

Andrew Coop, Ph.D.
 Associate Professor
Vice Chair of Academic Affairs

Department:
School of Pharmacy
Department of Pharmaceutical Sciences

UMGCC Research Program:
Experimental Therapeutics Program

Education/Training:
College Degree: MA, University of Oxford, UK
Ph.D., University of Bristol, UK

Contact Information:
Mailing Address: Health Sciences Facility II
20 Penn St., Rm. 637
Baltimore, MD 21201
Email: acoop@rx.umaryland.edu
Phone: 410-706-2029
Fax: 410-706-0346

Research Interests:
The design and synthesis of new chemical entities for the treatment of cancer. This involves collaborations with with a wide variety of researchers and clinicians in the field of oncology including biology, pharmacology, and computer-aided drug design.
Publications:
H. Wu, L. N. Thatcher, D. Bernard, D. A. Parrish, J. R. Deschamps, K. C. Rice, A. D. MacKerell, A. Coop: Position of Coordination of the Lithium Ion Determines the Regioselectivity of Demethylations of 3,4- Dimethoxymorphinans with L-Selectride. Org. Lett. 2005, 7, 2531-2534.

D. A. Parrish, L. N. Thatcher, H. Wu, A. Coop, J. R. Deschamps: 7-[E]-Benzylidene-14-hydroxy-3,4-dimethoxy-17-methylmorphinan-6-one. Acta Cryst. E. 2005, E61, o2617-o2618.

M. Spetea, E. Greiner, M. D. Aceto, L. S. Harris, A. Coop, H. Schmidhammer: Effect of a 6-Cyano Substituent in 14-Oxygenated N-Methylmorphinans on Opioid Receptor Binding and Antinociceptive Potency. J. Med. Chem. 2005, 48, 5052-5055.

W. E. Fantegrossi, A. W. Harrington, J. R. Eckler, R. A. Rabin, J. C. Winter, A. Coop, K. C. Rice, J. W. Woods: Hallucinogen-like actions of 2,5-dimethoxy-4-(n)-propylthiophenethylamine (2C-T-7) in mice and rats. Psychopharmacology 2005, 181, 496-503.

D. Bernard, A. Coop, A. D. MacKerell: Conformationally Sampled Pharmacophore (CSP) for Peptidic Delta Opioid Ligands. J. Med. Chem. 2005, 48, 7773-7780.

C. D. Cook, L. Biddlestone, A. Coop, P. M. Beardsley: Effects of Combining Ethanol with Gamma- Hydroxybutyrate (GHB) on the Discriminative Stimulus, Locomotor and the Motor-Impairing Actions of GHB in Mice. Psychopharmacology 2006, 185, 112-122.

W. Koek, W. Chen, S. L. Mercer, A. Coop, C. P. France: Discriminative Stimulus Effects of ã- Hydroxybutyrate: Role of training Dose. J. Pharmacol. Exp. Ther. 2006, 317, 409-417.

W. E. Fantegrossi, A. W. Harrington, C. L. Kiessel, J. R. Eckler, R. A. Rabin, J. C. Winter, A. Coop, K. C. Rice, J. H. Woods: Hallucinogen-like Actions of 5-Methoxy-N,N-diisopropyltryptamine in Mice and Rats. Pharmacol. Biochem. Behav. 2006, 83, 122-129.

W. Koek, L.P. Carter, H. Wu, A. Coop, C.P. France: Discriminative Stimulus Effects of Flumazenil: Perceptual Masking by Baclofen, and Lack of Substitution with Gamma-Hydroxybutyrate and its Precursors 1,4-Butanediol and Gamma-Butyrolactone. Behav. Pharmacol. 2006, 17, 239-247.

C. W. Cunningham, L. N. Thatcher, A. Coop: The Methylation of Non-acidic Alcohols of Alkaloids with TMS-Diazomethane: Conversion of Codeine to Codeine-6-methyl Ether. Heterocycles 2006, 68, 837-840.