Curt I. Civin, M.D. Samuelson Professor of Cancer Research; Director of the Center for Stem Cell Biology & Regenerative Medicine; Associate Dean for Research
Department:
Pediatrics
UMGCC Research Program:
Experimental Therapeutics Program
Education/Training:
College Degree:
B.A., Amherst College, Amherst, MA
Medical Degree:
M.D., Harvard Medical School, Boston, MA
Residency:
Children's Hospital Medical Center, Boston, MA
Contact
Information:
Mailing Address:
Bressler Research Building
14-021
University of Maryland School of Medicine
Baltimore, MD 21201
Email:
ccivin@som.umaryland.edu
Research Interests:
Biology of normal hematopoietic and other stem cells, Leukemia stem cells, Cancer stem cells, Hematologic malignancies, Genes and microRNAs involved in stem cell regulation
Publications:
Yu X, Zou J, Ye Z, Hammond H, Chen G, Tokunaga A, Mali P, Li Y-M, Civin C, Gaiano N, Cheng L. Notch signaling activation in human embryonic stem cells is required for embryonic but not trophoblastic lineage commitment. Cell Stem Cell 2008; 1:461-471.
Georgantas RW, 3rd, Bohana-Kashtan O, Civin C. Ex vivo soluble Fas ligand treatment of donor cells to selectively reduce murine acute graft versus host disease. Transplantation 2006;82:471-478.
Yu X, Alder JK, Chun JH, Friedman AD, Heimfeld S, Cheng L, Civin CI. HES1 inhibits cycling of hematopoietic progenitor cells via DNA binding. Stem Cells 2006;24:876-888.
Ravindranath Y, Chang M, Steuber CP, Becton D, Dahl G, Civin C, Camitta B, Carroll A, Raimondi SC, Weinstein HJ. Pediatric Oncology Group (POG) studies of acute myeloid leukemia (AML): a review of four consecutive childhood AML trials conducted between 1981 and 2000. Leukemia 2005;19:2101-2116.
Topaloglu O, Civin CI, Bunz F. Digital HLA allelotyping. Cancer Biol 2004;3:899-902.
Georgantas RW, Tanavde V, Malehorn M, Heimfeld S, Chen C, Carr L, Murillo F, Riggins G, and Civin CI. Microarray and SAGE analyses identify known and novel transcripts over-expressed in hematopoietic stem cells. Cancer Res 2004;64:4434-4441.
Angelopoulou M, Novelli E, Grove JE, Rinder HM, Civin C, Cheng L, and Krause DS. Cotransplantation of human mesenchymal stem cells enhances human myelopoiesis and megakaryocytopoiesis in NOD/SCID mice. Exp Hematol 2003;31:413-420.
