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Researcher Information

Stefanie N. Vogel, Ph.D.

Microbiology and Immunology

UMGCC Research Program:
Tumor Immunology and Immunotherapy
Experimental Therapeutics Program

College Degree: University of Maryland, College Park
Medical Degree: University of Maryland, College Park
Post Doctoral Degree: NIDR, NIH, Bethesda, Maryland
N. Cuesta, Q. M. Nhu, E. Zudaire, S. Polumuri, F. Cuttitta, and S. N. Vogel. Interferon Regulatory Factor-2 regulates macrophage apoptosis through a STAT1/3 and Caspase-1-dependent mechanism. J. Immunol. 178:3602-3611 (2007).

V. Y. Toshchakov, M. J. Fenton, and S. N. Vogel. Differential inhibition of TLR signaling pathways by cell-permeable peptides representing BB loops of Toll-like receptors. J. Immunol. 178:2655-2660 (2007).

A. E. Medvedev, W. Piao, J. Shoenfelt, S. H. Rhee, H. Chen, S. Basu, L. Wahl, M. J. Fenton, and S. N. Vogel. Role of TLR4 tyrosine phosphorylation in signal transduction and endotoxin tolerance. J. Biol. Chem. . 282: 16042-16053 (2007)

S. K. Polumuri, V. T. Toshchakov, and S. N. Vogel. Role of phosphatidylinositol-3 kinase in transcriptional regulation of TLR-induced IL-12 and IL-10 by FcgR ligation in murine macrophages. J. Immunol. 179: 236-246 (2007).

Z. J. Roberts, N. Goutagny, P.-Y. Perrera, H. Kato, S. Akira, R. Savan, D. van Echo, K. A. Fitzgerald, H. A. Young, L.-M. Ching, and S. N. Vogel. The novel chemotherapeutic agent, 5,6-dimethyxanthenone-4-acetic acid, potently and specifically activates the TBK1-IRF-3 signaling axis. J. Exp. Med. 204:1559-1569 (2007).

L. E. Cole, K. A. Shirey, E. Barry, A. Santiago, R. Rallabhandi, K. L. Elkins, A. Puche, S. M. Michalek, and S. N. Vogel. TLR2-mediated signaling requirements for Francisella tularensis LVS infection of macrophages. Infect. Immun. 75: 4127-4137 (2007).

A. A. Awomoyi, P. Rallabhandi, T. I. Pollin, E. Lorenz, M. B. Sztein, M. S. Boukhvalova, V. G. Hemming, J. C. G. Blanco, and S. N. Vogel. Association of TLR4 polymorphisms with symptomatic Respiratory Syncytial Virus infection in high-risk infants and young children. . J. Immunol. 179: 3171-3177 (2007).

Z. J. Roberts, L.-M. Ching, and S. N. Vogel. IFN-b-dependent inhibition of tumor growth by the vascular disrupting agent DMXAA (5,6-Dimethylxanthenone-4-acetic acid). J. Interferon Cytokine Res. 28: 133-139 (2008).

P . Rallabhandi, A.A. Awomoyi, K.E. Thomas, Y. Fujimoto, A. Phalipon, M.B. Sztein, S. Kusumoto, and S.N. Vogel. Differential activation of human TLR4 by E. coli and S. flexneri 2a lipopolysaccharide: Effect of lipid A acylation state and TLR4 polymorphisms on signaling, J. Immunol. 180: 1139-1147 (2008).

T. Shea-Donohue, K. E. Thomas, M. J. Cody, A. Zhao, L. J. DeTolla, K. M. Kopydlowski, M. Fukata, S. A. Lira, and S. N. Vogel. Mice deficient in the CXCR2 ligand, CXCL1 (KC/GRO-a), exhibit increased susceptibility to dextran sodium sulfate (DSS)-induced colitis. Innate Immun. 14: 117-124 (2008).

L. E. Cole, A. Santiago, E. Barry, T. J. Kang, K. A. Shirey, Z. J. Roberts, K. L. Elkins, A. S. Cross, and S. N. Vogel. The macrophage proinflammatory response to Francisella tularensis LVS requires coordination of multiple signaling pathways. J. Immunol. 180: 6885 -6891 (2008).