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Researcher Information

Louis DeTolla, V.M.D., Ph.D.
Director, Comparative Medicine Program
Chief, Veterinary Resources
Associate Professor

Department:
Pathology, Medicine (Infectious Diseases), Epidemiology and Comparative Medicine

UMGCC Research Program:
Tumor Immunology and Immunotherapy

Education/Training:
College Degree: M.S., Microbiology, Ph.D., Immunology, Rutgers University
Medical Degree: V.M.D. (Veterinary Medicine), University of Pennsylvania
Fellowship: Sloan-Kettering Institute, Immunobiology
Fox Chase Cancer Center (ICR), Oncology
Certification: Veterinarian License, PA and MD
Laboratory Animal Medicine

Contact Information:

Mailing Address: Louis J. DeTolla, V.M.D., Ph.D.
Director, Comparative Medicine
Chief, Veterinary Resources
University of Maryland School of Medicine
Comparative Medicine Program
10 South Pine St., MSTF, Room G-100
Baltimore, MD 21201-1192
Email: detolla@vetmed.umaryland.edu
Phone: 410-706-8537(8536)
Fax: 410-706-8538

Research Interests:
Development and use of animal models of cancer treatment. Gene therapy of transplanted mouse tumors. Topical and oral treatment of xenografted human cancer cells on immunodeficient mice.

Publications:
Smith, J.M., Rao, S.S., Stump, K.C., Benazzi, C., Sarli, G., DeTolla, L.J., Mammary
ductal carcinoma with comedo pattern in a rhesus macaque, Contemporatory Topics in
Laboratory Animal Science, July 2005, 44:29-33

Sarli, G., Preziosi, R., DeTolla, L., Brunetti, B., Benazzi, C., E-Caderhin immunoreactivity in canine mammary tumors, Journal of Veterinary Laboratory Investigation, November 2004, 16: 542-547

DeTolla, L.J., Catterton, T., Walker, J.H., Kenny, K.A., Hess, J.L., Highsmith, W.E. Development of anti- human telomerase monoclonals to characterize the behavior of human tumor xenografts in SCID mice. Abstracts of Scientific Papers  Platform and Poster Presentations at Annual Meeting of American Association for Laboratory Animal Science, Baltimore, MD, October, 2001.

Jiang, Q., DeTolla, L., Van Rooijen, N., Singh, I.S., Fitzgerald, B., Lipsky, M.M., Kane, A.S., Cross, A.S., and Hasday, J.D.: Febrile range temperature modifies early systemic tumor necrosis factor alpha expression in mice challenged with bacterial endotoxin. Infect Immun 67(4): 1539-1546, April, 1999

Xu, M., Kumar, D., Srinivas, S., DeTolla, L.J., Yu, S.F., Stass, S.A., and Mixson, A.J.: Parenteral gene therapy with p53 inhibits human breast tumors in vivo through a bystander mechanism without evidence of toxicity. Human Gene Therapy 8:177-185, 1997

DeTolla, L.J., Stump, K.C., Russell, R., Viskatis, L.J., Vidal, J.C., Newman, R.A., and Etcheverry, M.A.: Toxicity of the novel animal  derived anticancer agent, VRCTC-310: Acute and subchronic studies in beagle dogs. Toxicology 99: 31-46, 1995