UMGCC Research Program:
Experimental Therapeutics Program
Education/Training:
College Degree:
University of Michigan, Ann Arbor, MI
Post Doctoral
Degree:
Immunology, Yale University, New Haven, CT
Fellowship:
Biochemistry, University of California, Santa Barbara, CA,
Contact
Information:
Email:
dfarber@smail.umaryland.edu
Research Interests:
The focus of my research is on immunological memory, specifically the development, function, and regulation of memory T cells, using in vivo, cellular, molecular and biochemical approaches. We are actively engaged in dissecting the mechanisms by which memory T cells are generated and how they mediate protective rsponses of direct relevance to developing strategies to promote long-lived T cell immunity to cancer. We are particularly interested in the identifying signals that regulate the migration properties of memory T cells.
Publications:
Tang, A.L., Bingaman, A.W., Kadavil, E.A., Leeser, D.B., and Farber, D.L. (2006) "Generation and functional capacity of polyclonal alloantigen-specific memory CD4 T cells." Am. J. Transplant. 6:1275-1284. (editorial in the same issue by Fairchild, R., "Developing models to study the memory T cell barrier in transplantation", 6:1246-7)
Moulton, V., Bushar, N.D., Leeser, D., Patke, D.S. and Farber, D.L. (2006) "Divergent generation of heterogeneous memory CD4 T cells." J. Immunol. 177: 869-876.
Moulton, V. and Farber, D.L. (2006) Committed to memory: lineage choices for T cells. Trends Immunol. 27: 261-67.
Ndejembi, M.P., Patke, D.S., Bingaman, A.W., Chandok, M.R., Azimzadeh, A., Nadler,S.G., and Farber, D.L. (2006) Control of Memory CD4 T cell recall by the CD28 costimulatory pathway. J. Immunol. 177: 7698-7706.
Zhang, X., Dong, H., Lin. W., Voss, S., Hinkley, L., Westergren, M., Berry, D., Lewellen, D., Vile, R. Chen, L., Farber, D.L., and Strome, S.E. (2006) "Human Bone Marrow: a reservoir for enhanced effector-memory CD8 T Cells with potent recall function." J. Immunol. 177: 6730-7.
Shi, Q., Wang, D., Hadley, G.A., Farber, D.L. and Bartlett, S.T. (2006) "Abrogation of recurrent autoimmunity in the NOD mouse: a critical role for IL-4." Surgery. 140:281-288.
Ndejembi, M.P., Tang, A.L. and Farber, D.L. (2007) "Reshaping the Past: strategies for modulation of T cell memory." Clinical Immunology. 122:1-12.
Tang, A.L. and Farber, D.L. (2007) "Generation, homeostasis, and regulation of memory T cells in Transplantation." Current Opinion in Organ Transplantation. 12:23-29.
Chandok, M.R., Okoye, F.I., Ndejembi, M.P. and Farber, D.L. (2007) "A biochemical signature for rapid recall by memory CD4 T cells." J. Immunol. 179:3689-98.
Okoye, F.I., Krishnan, S., Chandok, M.R., Tsokos, G.C., and Farber, D.L. (2007) "Proximal Signaling control of human CD4 T cell function." Clin. Immunol. 125:5-15.
Tang, A.L., Njau, M.N., Teijaro, J.R., Azimzadeh, A., Nadler, S.G. and Farber, D.L. (submitted) "CTLA expression is an indicator and regulator of CD4+FoxP3+ T cell homeostasis."
Lin, M., Zhang, N, Teijaro, J. R., Stoica, C., Bona, C., McEvoy, R., Bromberg, J., Farber, D.L., Casares, S., and Brumeanu, T.-D. (2008) "A peptide-MHC II chimera avorssurvival of pancreatic ï? islets grafted in type 1 diabetic mice." Transplantation. In Press.
Verhoeven, D., Teijaro, J.R., and Farber, D.L. (2008) "Heterogeneous memory T cells in anti-viral immunity and immunopathology." Viral Immunology. In Press
Teijaro, J.R., Njau, M.P., Chandran, S., Nadler, S.G., Perez, D.R., Hasday, J and Farber, D.L. (submitted) Inhibiting CD28 costimulation uncouples memory T cell-mediated protection and immunopathology in influenza infection.
