H. Richard Alexander, M.D. Professor Associate Chair for Clinical Research
Department:
Surgery
UMGCC Research Program:
Experimental Therapeutics Program
Education/Training:
College Degree:
B.A., University of Colorado
Medical Degree:
M.D., Georgetown University School of Medicine
Residency:
General Surgery, National Naval Medical Center, Bethesda, Maryland
Fellowship:
Surgical Oncology, Memorial Sloan-Kettering Cancer Center, New York, New York
Certification:
American Board of Surgery
Contact
Information:
Mailing Address:
Associate Chairman for Clinical Research
Department of Surgery
University of Maryland School of Medicine
22 South Greene Street S4B05A
Baltimore, Maryland 21201
Email:
HRAlexander@smail.umaryland.edu
Phone:
410-328-3828
Research Interests:
Development of novel regional therapeutics for GI malignancies and other tumors that metastasize predominantly to liver or peritoneal cavity
Publications:
Alexander R, Libutti S, Bartlett D, Pingpank J, Kranda K, Helsabeck C, Beresnev T. Hepatic vascular isolation and perfusion for patients with progressive unresectable liver metastases from colorectal cancer refractory to previous systemic and regional chemotherapy. Cancer, Vol. 95(4): 730-6; August 15, 2002
Wang E, Miller LD, Ohnmacht GA, Mocellin S, Perez-Diez A, Petersen D, Zhao Y, Sinon R, Powell JI, Asaki E, Alexander, HR, Duray PH, Herlyn M, Restifo NP, Liu ET, Rosenberg SA, Marincola FM. Prospective molecular profiling of melanoma metastases suggests classifiers of immune responsiveness. Cancer Res, Vol. 1:62(13): 3581-6; July 2002.
Feldman AL, Costouros NG, Wang E, Qian M, Marincola FM, Alexander HR, Libutti SK. Advantages of mRNA amplification for microarray analysis. Biotechniques, Vol. 33(4): 906-12, 914; October 2002.
Weinreich DM, Elaraj DM, Puhlmann M, Hewitt SM, Carroll NM, Feldman ED, Turner ED, Spiess PJ, Alexander HR. Effect of Interleukin 1 Receptor Antagonist (IL-1ra) Gene Transduction on Human Melanoma Xenografts in Nude Mice. Cancer Res. 2003 Sep 15;63(18):5957-61.
Alexander HR Jr, Libutti SK, Pingpank JF, Steinberg SM, Bartlett DL, Helsabeck C, Beresneva T. Hyperthermic isolated hepatic perfusion using melphalan for patients with ocular melanoma metastatic to liver. Clin Cancer Res. 2003 Dec. 5;9(17):6343-9.
Feldman ED, Wu P, Beresneva T, Helsabeck C, Rodriguez M, Bartlett DL, Libutti SK, Pingpank JF, Alexander HR. Treatment of patients with unresectable primary hepatic malignancies using hyperthermic isolated hepatic perfusion. J Gastrointest Surg. 2004 Feb; 8(2): 200-207.
Pingpank JF, Libutti SK, Chang R, Wood BJ, Neeman Z, Kam AW, Figg WD, Zhai S, Beresneva T, Seidel GD, Alexander HR. Phase I study of hepatic arterial melphalan infusion and hepatic venous hemofiltration using percutaneously placed catheters in patients with unresectable hepatic malignancies. J Clin Oncol. 2005 May 20;23(15):3465-74.
Alexander HR, Libutti SK, Pingpank JF, Bartlett DL, Helsabeck C, Beresneva T. Isolated hepatic perfusion for the treatment of patients with colorectal cancer (CRC) liver metastases after irinotecan-based therapy. Ann Surg Oncol. 2005 Feb;12(2):138-44. Epub 2005 Feb 4.
Elaraj DM, Weinreich DM, Varghese S, Puhlmann M, Hewitt SM, Carroll NM, Feldman ED, Turner EM, Alexander HR. The Role of Interleukin 1 in Growth and Metastasis of Human Cancer Xenografts. Clin Cancer Res. 2006;12(4):1088-1095
