Department:
Basic Science Division, Institute of Virology
UMGCC Research Program:
Molecular and Structural Biology Program Viral Oncology
Education/Training:
College Degree:
B.S., University of Maryland, Department of Animal Science, College Park, MD
Medical Degree:
D.V.M., School of Veterinary Medicine, Tuskegee University, Tuskegee, AL
Residency:
Postdoctoral Scholar, Unit for Laboratory Animal Medicine, University of Michigan, Ann Arbor, MI
Contact
Information:
Mailing Address:
Room S161
Institute of Human Virology
725 W. Lombard Street
Baltimore, MD 21201
Email:
reid@umbi.umd.edu
Phone:
410-706-5828
Fax:
410-706-1127
Research Interests:
My research interests involve studying the development/maintenance of memory during HIV-1 infection, the role that apoptosis plays in this process and HIV-associated B cell lymphoma. I have produced a noninfectious HIV-1 transgenic rat which has normal CD4/8 T cell numbers but has an abnormal cytokine profile, severe B cell hyperplasia, a decreased expression of CD28 and Bcl-xL in CD4 T cells following activation, increased apoptosis and dysregulation in the development of effector/memory phenotype T cells. In this HIV-1 animal model, the associated immune abnormalities and B cell hyperplasia may be due to expression one or more of the HIV-1 proteins which may lead to abnormal T cell signaling. Our goals are to understand how expression of HIV gene products causes defects in the development or maintenance of T cell effector function and B cell hyperplasia in Tg rats and to identify the relevant viral gene.
Publications:
Reid W.C., Carmichael K.P., Srinivas S., Bryant J.L. Pathology Associated With the Use of Tribromoethanol (Avertin) in the Sprague-Dawley
Reid W., Sadowska, M., Lewis, G., Gallo R., Reitz, M. and Bryant, J et. al. An HIV-1 transgenic rat that develops HIV-related pathology and immunologic dsfunction. PNAS, Vol 98(16);2001.
H.-G. Guo, M. Sadowska, W. Reid, E. Tschachler, G. Hayward, and M. Reitz. Kaposi's Sarcoma-Like Tumors in a Human Herpesvirus 8 ORF74 Transgenic Mouse J Virol, Vol. 77(4); 2003.
Ray PE, Liu X-H, Robinson LR, Reid W, Xu L, Owens JW, Jones OD, Denaro F, Davis HG, Bryant JL. A novel HIV-Transgenic rat model of childhood HIV-1 -associated nephropathy. Kidney Int Vol 63; 2003.
W. Reid, S. Abdelwahab, M. Sadowska, D.Huso, A. Neal, J. Bryant, R.C. Gallo, G. Lewis and M. Reitz. HIV-1 Transgenic Rats Develop T-Cell Abnormalities, Virology, Vol. 321 (1); 2004.
Mazzucchelli R, Amadio M, Curreli S, Denaro F, Bemis K, Reid W, Bryant J, Riva A, Galli M, Zella D., Mol Immunol., Vol. 41(10):979-84 2004.
