UMGCC Research Program:
Hormone Responsive Cancers Program
Contact
Information:
Mailing Address:
UM Department of Pharmacology
655 W. Baltimore St.,
Bressler Research Building, Rm. 4-002
Baltimore, MD 21201
Email:
yqiu@som.umaryland.edu
Phone:
410-706-4535
Fax:
410-706-0032
Research Interests:
molecular mechanisms of signal transduction by tyrosine kinases in prostate cancer progression
Publications:
Yun Qiu , L. Ravi and Hsing-Jien Kung. 1998. Requirement of erbB2 for activation of MAP kinase by Interleukin-6 in Prostate Cancer cells. Nature, 393: 83-85.
Yun Qiu, Don Robinson, Tom Pretlow and Hsing-Jien Kung. 1998. Etk, a tyrosine kinase with a PH domain, is an effector of PI3 Kinase and involved in IL6 induced neuroendocrine differentiation of prostate cancer cells. Proc. Natl. Acad. Sci., 95: 3644-3649.
Yun Qiu and Hsing-Jien Kung. 2000. Signaling network of the Btk Family Kinases. Oncogene,19:5651-61 (Review).
Riyan Chen, Oekyung Kim, Ming Li, Xinsheng Xiong, Jun-Lin Guan, Hsing-Jien Kung, Hegang Chen, Yoji Shimizu and Yun Qiu. 2001. Regulation of the PH-domain-containing tyrosine kinase Etk by Focal Adhesion Kinase through the FERM Domain. Nature Cell Biology, 3: 439-444.
Riyan Chen, Oekyung Kim, Jiangbo Yang, Kanoka Sato, Kathryn M. Eisenmann, James McCarthy, Hegang Chen, and Yun Qiu. 2001. Regulation of Akt/PKB Activation by Tyrosine Phosphorylation. J. Biol. Chem., 276, 31858-31862.
Jianbo Yang, Oekyung Kim, Jie Wu and Yun Qiu. 2002. Interaction between tyrosine kinase Etk and a RUN-domain and FYVE-domain containing protein RUFY1: A possible role of Etk in regulation of vesicle trafficking. J. Biol. Chem., 277: 30219-30226.
Oekyung Kim, Jianbo Yang and Yun Qiu. 2002. Selective Activation of Small GTPase RhoA by Tyrosine Kinase Etk through its PH domain. J. Biol. Chem., 277: 30066-30071.
Tianyun Jiang and Yun Qiu. 2003. Interaction between Src and a C-terminal Proline-rich Motif of Akt is Required for Akt Activation. J. Biol. Chem., 278: 15789 - 15793.
Oekyung Kim, Tianyun Jiang, Yingqiu Xie, Zhiyong Guo, Hegang Chen and Yun Qiu. 2004. Synergism of Cytoplasmic Kinases in IL6-Induced Ligand-independent Activation of Androgen Receptor in Prostate Cancer Cells. Oncogene, 23:1838-1844.
Tianyun Jiang, Zhiyong Guo, Bojie Dai, Miyoung Kang, David K. Ann, Hsing-Jien Kung and Yun Qiu. 2004. Bi-directional Regulation between Tyrosine Kinase Etk/BMX and Tumor Suppressor p53 in Response to DNA Damage. J. Biol. Chem., 279: 50181 - 50189.
