Department:
Institute of Human Virology, Animal Models Division (UMBI)
UMGCC Research Program:
Viral Oncology Experimental Therapeutics Program
Education/Training:
College Degree:
D.V.M., Tuskegee University, Tuskegee, AL
M.S., University of Missouri, Columbia, MO
B.S., Tennessee State University, Nashville, TN
Post Doctoral
Degree:
University of Missouri, Columbia, MO
Postdoctoral Fellow
Residency:
University of Missouri, Columbia, MO
Certification:
Board Certified Veterinarian in Laboratory Animal Medicine
Contact
Information:
Mailing Address:
Institute of Human Virology, Animal Model Division
Medical Biotechnology Building
725 W. Lombard Street, Rm. S110
Baltimore, Maryland 21201
Email:
bryant@umbi.umd.edu
Phone:
410-706-2754
Fax:
410-706-5664
Research Interests:
My research team at the IHV has created the first transgenic rats whose DNA has been manipulated to incorporate genes of HIV-1. The rat model opens new areas of human HIV/AIDS study for scientists; its potential enhanced by similarities in the structure of the rat genome with humans.
Other research efforts focus on the mechanisms of human diseases caused by viruses and on details of virus replication to develop better therapies and improved or new diagnostics. The current focus of this work is on the continual development of animal models for AIDS and AIDS-associated malignancies, such as Kaposi's sarcoma and B-cell lymphoma, as well as animal models for breast and prostate cancer.
Publications:
Izevbigie EB, Bryant JL, Walker A, A Novel Natural Inhibitor of Extracellular Signal-Regulated Kinases and Human Breast Cancer Cell Growth, Exp Biol Med(Maywood) 2004, February 229 (2): 163-9
Ray PE, Liu XH, Robinson LR, Reid W, Xu L, Owens JW, Jones OD, Denaro F, Davis HG, Bryant JL, A Novel HIV-1 Transgenic Rat Model of Childhood HIV-1 Associated Nephropathy, Kidney Int., 2003; June 63(6):2242-2253
Mozes MM, Bryant JL, Franks R, Chan CC, Kopp JB., Congenital Nuclear Cataracts and Uveitis in HIV-Transgenic Mice, Eye 2002, Mar;16(2):177-84
Pati S, Pelser CB, Dufraine J, Bryant JL, Reitz MS Jr., Weichold FF, Antitumorigenic Effects of HIV protease Inhibitor Ritonavir: Inhibitor of Kaposi Sarcoma, Blood 2002, May 15;99(10): 3771-9
W. Reid, M. Sadowska, F. Denaro, S. Rao, J. Foulke, Jr., N. Hayes, O. Jones, D. Doodnauth, H. Davis, A. Sill, P. O'Driscoll, D. Huso, t. Fouts, G. Lewis, M. Hill, R. Kamin-Lewis, C. Wei, P. Ray, R.C. Gallo, M. Reitz, and J. Bryant, An HIV-1 transgenic rat that develops HIV-related pathology and immunologic dysfunction, PNAS 2001 Jul Vol 98, No 16;9271-9276
