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Researcher Information

Elena N. Klyushnenkova, Ph.D.
Research Investigator
Adjunct Assistant Professor

Department:
VA Maryland Health Care System, Baltimore
Department of Surgery

UMGCC Research Program:
Tumor Immunology and Immunotherapy

Education/Training:
College Degree: Moscow State University, Russia
Post Doctoral Degree: Russian State Medical University, Russia
Fellowship: 1993-1995, Laboratory of Cellular Immunology,
Alton Ochsner Medical Foundation, New Orleans, LA
1995-1997 Department of Neurology, University of Maryland School of Medicine, Baltimore, MD

1999-2001 Department of Surgery, University of Maryland School of Medicine, Baltimore, MD

Contact Information:

Mailing Address: University of Maryland School of Medicine
Department of Surgery
10 S. Pine Street, MSTF Room 4-00A
Baltimore MD 21201
Email: eklyushnenkova@smail.umaryland.edu
Phone: 410-706-0755 (office)
410-706-1810 (lab)
Fax: 410-706-0311

Research Interests:
Autoimmune response to prostate differentiation antigens – implication for prostate cancer immunotherapy.

Factors of innate immunity in the development of anti-tumor immune responses – implication for prostate cancer immunotherapy

Tumor-mediated immunosuppression

Publications:
Klyushnenkova E. N., and Malaytsev, V.V. 1992. Development of interleukin-6-dependent hybridoma. Bulletin of Experimental Biology and Medicine, 8:179-181.

Klyushnenkova, E.N., Lutskaya T. D., Golenkov, A. K., and Malaytsev, V. V. 1993. Interleukin-1 and interleukin-6 production by peripheral blood and bone marrow mononuclear cells in patients with multiple myeloma. Bulletin of Experimental Biology and Medicine 5:555-558.

Kim, H.-S., X. Zhang, E.N. Klyushnenkova, and Y.S. Choi. 1995. Stimulation of germinal center B lymphocyte proliferation by FDC-like cell line, HK. J. Immunol. 155:1101-1109.

Klyushnenkova, E. N., L. Li, R.J. Armitage, and Y.S. Choi. CD48 provides an accessory signal for CD40-mediated activation of human B cells. 1996. Cell. Immunol. 174: 90-98.

Klyushnenkova, E. N., and P. Vanguri. 1997. Ia expression and antigen presentation by glia: strain and cell type-specific differences among rat astrocytes and microglia. J. Neuroimmunol. 79:190-201.

Biragyn A., M. Surenhu, D. Yang, P.A. Ruffini, B.A. Haines, E. Klyushnenkova, J.J. Oppenheim, and L.W. Kwak. 2001. Factors of innate immunity which target immature, but not mature dendritic cells induce antitumor immunity when genetically fused with non-immunogenic tumor antigens. J. Immunol. 167:6644-6653.

Biragyn,A., P.A.Ruffini, C.A.Leifer, E.Klyushnenkova, A.Shakhov, O.Chertov, A.K.Shirakawa, J.M.Farber, D.M.Segal, J.J.Oppenheim, and L.W.Kwak. 2002. Toll-like receptor 4-dependent activation of dendritic cells by beta-defensin 2. Science 298:1025-1029.

Klyushnenkova, E., Ponniah, S., Rodriguez, A, Kodak, J, Mann, D. L., Langerman, A, Nishimura, M., and Alexander, R. B. 2004. CD4 and CD8 T lymphocytes recognition of prostate specific antigen in granulomatous prostatitis. J. Immunotherapy, 27(2):136-146.

Alexander, R.B., D.L. Mann, A.A. Borkowski, M. Fernandez-Vina, E.N. Klyushnenkova, J. Kodak, K.J. Propert, and M. Kincaid. 2004. Granulomatous prostatitis linked to HLA-DRB1*1501. J. Urology, 17(6/1): 2326-2329.

Klyushnenkova, E., J. D. Mosca, V. Shustova, M. K. Majumdar, K. J. Beggs, D. W. Simonetti, R. J. Deans, and K. R. McIntosh. T Cell Responses to Allogeneic Human Mesenchymal Stem Cells: Immunogenicity, Tolerance, and Suppression. J.Biomed.Sci, in press.