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Trilogy Archive Questions

Below are Dr. Regine’s answers to Trilogy questions
received through the Ask the Expert feature.

This content is provided for informational purposes only, and is not intended
to be a substitute for individual medical advice in diagnosing or treating a
health problem. Please consult with your physician about your specific health
care concerns.




Now displaying records 1 to 15 of 30.

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Q : 1

10/28/2009
We recently found out that my mother has tumors on her liver. We aren't sure if they are malignant or not, but I wanted to know if Trilogy radiation is able to treat innumerable tumors on a person's liver. Thank you.

For "innumerable" tumors, we would generally first think about use of Sir-Spheres (Radioactive microbeads injected directly into liver) as part of our liver-directed therapy program arsenal.


Q : 2

10/11/2009
Can the Trilogy system be used in the treatment of vulvar cancer?

The IGRT (Image-guided Radiation Therapy) and IMRT (Intensity Modulated radiation Therapy) capabilities would likely be used, thus ensuring the most accurate and precise delivery of radiation therapy for your vulvar cancer. My office number is 410-328-2326, if I can be of further assistance.


Q : 3

09/08/2009
My husband has a small--approx. 1cm melanoma lesion in his right posterior iliac bone, near the SI joint. It lights up on the PET/CT and shows a low-density lytic lesion with some thinning of the cortical bone. Is this amenable to Trilogy treatment? What are the risks and chances of cure?

It is in the context of his general condition and overall cancer status. Risks, generally <5%, including nerve/bone damage. Melanoma spread to the bone is generally not viewed at "curable" per se, but can be associated with long-term survival. We have a comprehensive melanoma oncology team I could make available to you. Please call my office if I can be of further assistance.


Q : 4

09/06/2009
Does the use of Trilogy treatment make radiation more available to patients that may have had heavy radiation in the past, (say 9 years ago)?

Yes, it does, given the capabilites related to increased precision.


Q : 5

08/01/2009
Can you use trilogy on tumors inside the spinal cord? Can trilogy still be used if traditional radiation has already been used?

Yes. It will depend on the amount of previous radiation, how long ago, area of spinal canal etc. We actually have a spine-directed oncology team that meets once a week to review patients with problems like you have described. My office number is 410-328-2326 if I can be of any further assistance.


Q : 6

07/22/2009
What is the difference between Trilogy and RapidArc for prostate treatment?

RapidArc is the software that allows for rapid and precise delivery of radiation delivered from the Trilogy machine.


Q : 7

07/18/2009
My mother is 95 years old. She dad breast cancer 4 years ago. Now she has lung cancer. She had radiation and the tumor shrank. It has now moved into her adrenal gland and chest. I need to know if Cyberknife or anything can be done for her.

Stereotactic body radiation therapy may be able to be done. This is something we do with our Trilogy Radiation Therapy. It is the latest in radiation delivery systems and has capabilities that the Cyberknife unit does not have. We were the first in the Mid-Atlantic with this system and have the longest experience. Feel free to contact me if I can be of further assistance.


Q : 8

07/16/2009
My husband was diagnosed with advanced nsc lung cancer. He has a 10x5cm tumor on his upper right lung that has spread to a lymph node on his right jawline. He has had two rounds of chemo (cisplatin and gemzar) thus far. The jawline lesion has reduced significantly, but the lung tumor has remained resistant, although a recent scan showed that it has not spread or grown. Do you think my husband is a possible candidate for Trilogy? He is scheduled to begin further rounds of chemo shortly.

He possibly would be. We have a nationally recognized team of experts in lung cancer. I would be happy to put you in connection with as need be. Please call my office to discuss.


Q : 9

05/19/2009
My husband has a tumor (metastatic, poorly differentiated carcinoma with neuroendocrine features) in the right atrium of the heart. The tumor measures 7.9cm x AP 9.9 cm and was found in October. He has been receiving chemotherapy for the last 6 months and while the tumor has not grown, there has only been minimal shrinkage. Could Trilogy work for him?

His case is challenging, but I think that the capabilities of Trilogy coupled with an experienced Radiation Oncologist could be a successful treatment option for your husband.


Q : 10

04/10/2009
My brother has been diagonosed with non-small-cell cancer in the lung; he underwent 6 cycles of chemotherapy with Pemgem & Nanoxel. Unfortunately, the result has not been positive. Our doctor has advised to go for localized radiation. Will this technology help? His tumor size is 4.1 x 4.8 x 5.3 cms.

Trilogy-specific "radiation therapy" is not likely to be significantly better then conventional linear accelerator based "radiation therapy" in this situation, at least not enough so that he should travel this far from India.


Q : 11

03/22/2009
I have a leiomyosarcoma of the paraspinal muscle that has not invaded the spine and or bone. Is this a condition that has been treated before by Cyberknife?

We use the Trilogy system, the state-of-the-art radiation treatment system which has functions that are in addition to what the Cyberknife can do. My office number is 410-328-2326, if I can be of further assistance.


Q : 12

03/09/2009
Can the Trilogy machine treat an acoustic neuroma of approximately 2x2cm?

Yes. We also have a Gamma Knife and have treated over 2,600 patients with it. It is also proven very effective for the treatment for acoustic neuroma. My office number is 410-328-2326 if I can be of any further assistance.


Q : 13

12/05/2008
Can Trilogy be effective if a person has pancreatic cancer that involves the SMA. The tumor had been pushing into the duodenum, so surgery was done to cut back the small intestine. It was diagnosed as stage 3 and to my knowledge has not spread to any other organs.

Yes, Trilogy can be used for this type of cancer in conjunction with chemotherapy. It would likely be used in its IMRT (intensity modulated radiation therapy) and/or its IGRT (image guided radiation therapy) modes.


Q : 14

05/04/2008
Are you currently using Triology to treat prostate cancer? If so, for how long has it been used? Is it considered better than Cyberknife treatment alone?

Yes, we have, for about two years. It is more versatile than the Cyberknife in terms of capabilites and is considered a newer generation linear accelerator-based system. My office number is 410-328-2326 if I can be of further assistance.


Q : 15

02/18/2008
What has your experience been in using Trilogy for patients with Stage IV pancreatic cancer? (This particular patient is very healthy and has excellent performance status, except for the tumor.) Are there any published reports or clinical trial results on use of Trilogy for this type of cancer? Many thanks!

Not a major indication for stage 4 pancreas cancer with liver mets. However, for those who have localized disease to the pancreas only and are unresectable, we are using it and reducing acute treatment side effects. We hope to present this experience at our national meeting later this year.


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