UMM logo

A Member of the University of Maryland Medical System   |   In Partnership with the University of Maryland School of Medicine


Email PageEmail Print PagePrint
Find a Doctor Become a Patient University of Maryland Medical Center Ask an Expert Getting Here Contact Us Site Map 1-800-492-5538

Ask The Expert Archive

For an Appointment Call: 410-328-0000

NanoKnife IRE Archive Questions

Below are Dr. Moeslein’s answers to NanoKnife IRE questions
received through the Ask the Expert feature.

This content is provided for informational purposes only, and is not intended
to be a substitute for individual medical advice in diagnosing or treating a
health problem. Please consult with your physician about your specific health
care concerns.

Now displaying records 1 to 5 of 5.


Q : 1

What is the max size of a legion that can be treated successfully with the NanoKnife?

There is no "max size," but once lesions get beyond 4 cm, they become very difficult to treat with IRE alone. However, the answer is really more about location, surrounding tissues, and the path that would be necessary to take in order to direct the probes into the mass, and tumor type.

Q : 2

I have prostate cancer and am wondering if I am a candidate for IRE. How many prostate cancer patients have you treated in this way? Are there any situations where you would not suggest IRE for prostate caner that is contained in the prostate? Of the people you have treated in this way for prostate caner, how many have achieved the trifecta?

I have had very good success with treating prostate cancer. So far, the patients have maintained urinary continence, been able to regain erectile function within 3-6 months, and so far have seen complete control of their cancer.

Q : 3

Can the NanoKnife be used on five pancreatic cancer mets in my liver (one at 1.7cm, the rest less than 1cm)?

For stage IV pancreatic cancer, especially multifocal disease, we at UMMC have been using SIRT (in our case it is SirSpheres) to treat our patients, and have had good success.

Q : 4

Can NanoKnife IRE be used to treat a malignant prostate?

It would depend on the size of the lesions and exactly what they are anatomically. I would need to review your history and imaging, but I am willing to do that before having you in for a consult. The NanoKnife is not without potential side effects, but certainly it is possible to ablate in that area of the body, and I have already done so in other patients with success.

Q : 5

Can this treatment be used for thyroid cancer?

It probably could, but thyroidectomy is usually well tolerated, very effective, and has a long track record of success, so unless there is a reason not to undergo the standard of therapy, I would be hard pressed to recommend IRE. However, in the setting where surgery is not feasible, or in the case of recurrent disease, IRE may be an option.


For patient inquiries, call 1-866-408-6885 or click here to make an appointment.